High-purity and label-free isolation of circulating tumor cells (CTCs) in a microfluidic platform by using optically-induced-dielectrophoretic (ODEP) force

pubs.rsc.org/en/content/articlepdf/2013/lc/c3lc41256c

Veridex and LabCorp Agreement Brings CELLSEARCH® CTC Test to China

Headline Story | equities.com

Circulating Tumor Cell ( CTC ) market info

Below is a compilation of publicly available market info from various sources

Market Potential

A recent market report was published by Transparency Market Research (http://www.transparencymarketresearch.com) titled "Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market - Global Scenario, Trends, Size, Growth and Industry Analysis, 2011 - 2018." Globally, CTCs and CSCs Market is estimated to reach USD 7.9 billion by 2018. The global market for cancer diagnostics based on Circulating Cancer Cells (CTCs) was estimated at USD 1.0 billion in 2011. Majority of the share is most likely held by Veridex LLC (Johnson and Johnson)

CTC market estimates used by other CTC companies

company	Price/test	Market size	comment
Creatv Microtech [1]	USD 600	10-20 Bln	20-30 mln tests in US. 1 test/year/patient
Ikonisys [2]	USD 400	35 Bln	Total Addressable Market: 4 Bln (monitoring), 35 Bln (early detection)
Parsortix (listed) [3]	na	4 Bln	Est. 20,000 separations from single pharma site p.a. 25 Mln p.a. early stage rev.
Rheoblast [4]	na	5.2 Bln	10 Mln US patients= 25 M tests/year. 2-3 tests/yr/pat. 6000 clinical labs in US (2-3% growth) 1400 cancer treatment centers in US (6-7% growth) 150 biomarker companies and research labs

[1] http://www.creatvmicrotech.com/Documents/cmt_ctc.pdf

[2] http://www.availablepharmaproducts.com/ikon-ctc.pdf

[3] https://docs.google.com/open?id=0B6AYySNe0mJCTTd0Sll4NVhZMGs

[4] http://lsdfa.org/dev/documents/pdfs/LSDF_Chiu_Post.pdf

Figure 4:  source [4]

CTC application segment	CAGR
Prognosis	-
Therapy monitoring	26.54%
Diagnostics	26.48%

Prognostic functions hold 58.28% of the total CTC Technologies market

Table source: CIRCULATING TUMOR CELL (CTC) TECHNOLOGIES - A MARKET INSIGHT REPORT

Figure 5 is the estimated market share by a CTC company, Silicon Biosystems, which provides solution for cell sorting.

Figure 6 is the estimated market share by a CTC company, Filtini, which provides microfilter based CTC isolation device

The demand for cellular analysis will also expand significantly during the next five years. This sector was worth $10 million in 2010 and is expected to increase at a 95.4% compound annual growth rate (CAGR) to reach $296 million in 2015.

List of all active commercial circulating tumor cell ( CTC ) technologies is here
http://circulating-tumor-cells.blogspot.com/2010/12/commercial-circulating-tumor-cell-ctc.html

other documents of interest
https://docs.google.com/file/d/0B6AYySNe0mJCTTd0Sll4NVhZMGs/edit?usp=sharing

Probing circulating tumor cells in microfluidics - Latest review paper on Microfluidic CTC technologies

Probing circulating tumor cells in microfluidics - Lab on a Chip (RSC Publishing) DOI:10.1039/C2LC90148J

this is a review paper detailing the latest developments in microfluidics based circulating tumor cell isolation and analysis.

High-purity and label-free isolation of circulating tumor cells (CTCs) in a microfluidic platform by using optically-induced-dielectrophoretic (ODEP) force - Lab on a Chip (RSC Publishing)

High-purity and label-free isolation of circulating tumor cells (CTCs) in a microfluidic platform by using optically-induced-dielectrophoretic (ODEP) force - Lab on a Chip (RSC Publishing)

Biologic Challenges in the Detection of Circulating Tumor Cells

Biologic Challenges in the Detection of Circulating Tumor Cells

review by Klaus Pantel, a notable opinion leader in CTC

Circulating Tumor Cells: Personalized Medicine in Interventional Oncology?

ScienceDirect.com - Journal of Vascular and Interventional Radiology - Circulating Tumor Cells: Personalized Medicine in Interventional Oncology?

This is the latest review paper on circulating tumor cell (CTC) technology and application.