Label-free isolation of circulating tumor cells in microfluidic devices: Current research and perspectives
This paper is quite comprehensive in covering the many label free approaches to CTC isolation reported so far, including, filters, accoustophoresis, magnetophoresis, etc.
The general recommendation of the paper is towards adoption of these technologies for clinical use.
undoubtedly, there are several advantages to label-free isolation of CTCs, specially filtration techniques, which are simple, inexpensive, fast and easy to use. However, there are some important limitations that need to be considered, which I was hoping the paper would shed light upon, but didnt.
the general limitations of filtration techniques are listed here.
It was also recently reported that the deformability of tumor initiating cells is less differentiated from normal blood cells. This makes the sized and deformability based techniques vulnerable to missing these important subtypes of CTCs. This is covered here
It was also recently reported that the deformability of tumor initiating cells is less differentiated from normal blood cells. This makes the sized and deformability based techniques vulnerable to missing these important subtypes of CTCs. This is covered here
No comments:
Post a Comment