Wednesday, May 22, 2013

Chemosensitivity testing using CTCs from patient samples

Chemosensitivity Testing of Circulating Epithelial Tumor  Cells (CETC) in Vitro: Correlation to in Vivo Sensitivity  and Clinical Outcome
www.laborpachmann.de/pdf/Chemosensitivity_JCT_2013.pdf

interesting paper and opens up new application area for CTCs.

Method for isolation: RBC lysis followed by image analysis of all nucleated cells

Conclusion: "Thus, we are able to show that chemosensitivity testing of circulating tumor cells provides real-time information about the sensitivity of the tumor present in the patient, even at different times during therapy, and correlates with treatment success. "

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