ScienceDirect.com - Biosensors and Bioelectronics - High throughput capture of circulating tumor cells using an integrated microfluidic system
"we achieved an enrichment factor of 1500X, and a high processing throughput of 9.6 mL/min with
90% capture yield and more than 50% capture purity at cell concentration 102 cells/mL"
I believe this is the highest reported throughput with 90% capture efficiency. Impressive!
The principle used in isolation is a combination of Deterministic lateral displacement (DLD) and EpCAM-based capture.
Most of you know about EpCAM based capture on microposts. Below is a video on how DLD works
some related prior art:
"we achieved an enrichment factor of 1500X, and a high processing throughput of 9.6 mL/min with
90% capture yield and more than 50% capture purity at cell concentration 102 cells/mL"
I believe this is the highest reported throughput with 90% capture efficiency. Impressive!
The principle used in isolation is a combination of Deterministic lateral displacement (DLD) and EpCAM-based capture.
Most of you know about EpCAM based capture on microposts. Below is a video on how DLD works
some related prior art:
